● Project Background:
Toxicological tests are experiments in which experimental animals are exposed to different routes and different periods of time to detect various toxic end points. To clarify the toxicity and potential hazards of a chemical through animal experiments and observations on animals, the purpose is to determine the level of harmless effect, type of toxicity, target organs, and dose-response relationship to provide important information for safety evaluation or risk evaluation. Toxicological testing plays an important role in ensuring the safety of food, health food, cosmetics, disinfection products, drugs, medical devices and chemical products.
The animal laboratory of Pony Testing Group obtained 6 licenses for the use of experimental animals in 2018. The whole facility consists of three parts, including 800 square meters of SPF level barrier animal feeding facilities, 200 square meters of ordinary level animal feeding facilities, and 200 square meters of affiliated laboratories. The SPF barrier facilities are mainly used for the breeding of SPF rats and mice, and the ordinary facilities are mainly used for the breeding of ordinary rabbits and guinea pigs. The affiliated laboratories included reagent room, physiological and biochemical test laboratory, pathology laboratory, Ames laboratory, cell laboratory and archive room, which were equipped with automatic biochemical analyzer, blood cell counter, hemagglutination analyzer, urine analyzer, blood glucose analyzer, microplate reader, biological safety cabinet, automatic dehydrator, automatic dyeing machine, embedding machine and microtome.
● Test items:
| Acute oral toxicity test of hazardous wastes | Acute oral toxicity tests of chemicals |
| Acute percutaneous toxicity test of hazardous wastes | Chemical acute skin irritation/corrosive tests |
| Acute inhalation toxicity test of hazardous wastes | Acute inhalation toxicity test of chemicals |
| Determination of acute toxicity of water quality | Acute transcutaneous toxicity testing of chemicals |
| Acute oral toxicity tests for water and aquatic products | Chemical skin sensitization test |
| Bacterial reverse mutation tests in water and aquatic products | Chemical acute eye irritation/corrosive tests |
| Micronucleus tests of mammalian cells in water and wading products | Bacterial reverse mutagenesis assay for chemicals |
| Acute oral toxicity test of microbial fertilizer (limit method) | Chemical micronucleus test |
| Oral toxicity test of fertilizers and soil conditioners (limit method) |
